Carboxylic cation exchange resin effects in dogs.

Reports describing trials of exchange resins in removing cations from the gastrointestinal tract of experimental animals have been limited to toxicity studies and to measurements of the relative magnitudes of the oral intake and the stool output (1-3). In the experiments presented in this paper changes in serum, urine, and stool components, as well as the external and internal balances of certain electrolytes and of nitrogen have been determined in dogs receiving a carboxylic cation exchange resin in one of two forms. The chemical and physical characteristics of these agents have been described in detail in the introductory paper (4).